Projects Funded by NAFOSTED


No

Project title / Project ID

Principal investigator

Objectives

Expected outcomes

Implementation time

 

Department of Advanced Materials Science and Nanotechnology (AMSN): 03 projects

 

1

Innovative (Photo)Catalysts for Solar Hydrogen Generation from Water (iCatH2).

ID: 103.99-2015.46

Dr. Tran Dinh Phong

Design and preparation of novel electrocatalytic and photocatalytic materials based on earth abundant elements for solar H2 generation from water.

- Technical Products:

+ Design and preparation of novel electrocatalytic nanomaterials based on sulfide of transition metals as potential alternatives for Pt HER catalyst;

+ Preparation of novel photocatalytic nanomaterials/ photoelectrodes for solar H2 generation by integrating novel sulfide HER catalysts (above) with appropriate light harvesters (Si, Cu2O).

- Publications:

+ 03 ISI papers including 01 Q1 journal paper and 20 Q2 journal papers;

+ 01 paper in national journal;

+ 01 presentation within international/ national conference/ workshop.

- Training: Participate in training of 01 PhD student and 02 Master students.

3 years

(2016 - 2019)

2

Elaboration of hybrid immunosensor based on dual channel tranduction mechanisms: electrochemical and surface plasmon resonance detection for determining organic pollutants in waters.

ID: 103.02-2016.45

Dr. Nguyen Van Quynh

The main objective of the project is to develop a new hybrid immunosensor based on a dual channel transduction mechanism: Electrochemical and Surface Plasmon Resonance for determining organic pollutants in waters. Two different types of signals are recorded simultaneously under the same biochemical reactions, one measured signal can be a reference to the other and consequently, a double confirmation of the comparative results can be obtained. This ensures the fidelity and accuracy of the analytical results.

- Technical Products:

+ The project will provide various efficient methods to synthesize functionalized hybrid material (BTB-JUGlone-Hapten-AuNPs) for biosensors;

+ After the ending of this research project, we are confident that the prototypes of hybrid immunobiosensors based on dual transduction mechanism will be available. This novel hybrid immunosensors will be applied to detect a popular water pollutant such as diclofenac.

- Publications:

+ 01 ISI paper;

+ 01 paper in qualified International Scientific Journals;

+ 02 papers in National Scientific Journals;

+ 02 presentations within international/ national conference/ workshop.

- Training: 02 Masters.

2 years

(2017 - 2019)

3

Strain Gradient Plasticity Models: Application in Micromechanics.

ID: 107.02-2014.26

Dr. Luu Duy Hao

NA

- Publications:

+ 01 ISI paper;

+ 02 presentations within international/ national conference/ workshop.

- Training: 01 Master.

2 years

(2015 - 2017)

 

Department of Pharmacological, Medical and Agronomical Biotechnology (PMAB): 03 projects

 

4

Discovery of QTLs associated with the sensitivity to Jasmonic acid that link to stress tolerance in Vietnamese rice collection using Genome Wide Association Study.

ID: 106-NN.03-2016.15

Dr. To Thi Mai Huong

In this proposal, we focus on the diversity of our traditional rice resources for:

- Detecting the natural variations in the sensitivity to JA that exists in Vietnamese rice germplasm to discovery some significant QTLs that relates to the JA sensitivity;

- Evaluating the correlation between the JA less sensitivity of these accessions and their tolerance to stress;

- Evaluating the local and systemic response of rice to salt stress and to wounding by specific markers that associated with JA sensitivity or using JA biosensor.

- Technical Products:

+ New knowledge on QTLs linked to JA sensitivity in rice identified via GWAS;

+ The correlation and its strength between JA sensitivity and stress adaptation / response in rice;

+ A novel tool to investigate the perception and distribution of JA in rice using JA biosensor and JA markers.

- Publications:

+ 2 publications in qualified ISI journal;

+ 1 publication in qualified Vietnamese journal.

- Training: 2 Master students.

3 years

(2017 - 2020)

5

Metabolomics approach for correlation evaluation between heavy metal levels – secondary metabolites contents – bioactivities of Pteris vittata growing in several metalliferous areas in the North of Vietnam.

Dr. Nguyen Thi Kieu Oanh

- Evaluate the accumulation ability of hyperaccumulator plant growing in metalliferous soils in order to propose an environmental treatment by phytoremediation;

- Evaluate the relationship between HMs level, SMs content and bioactivity of these hyperaccumulator plant.

- Technical Products:

+ A report on the accumulation ability of plant growing on several mining locations in the North of Vietnam.

+ A better understanding of the change at the metabolic level of hyperaccumulator plants growing in areas with high metal concentrations in comparison with control. These plants thus produce more secondary metabolites which represent interesting biological activities such as antioxidant.

+ This project is willing to identify the compounds which play an important role in the mechanism of plant adaptation to extreme conditions of heavy metal. By the way, it could be expected to clarify the defense mechanisms of hyperaccumulatior plants.

+ Finding a new method in natural compound research: using a comprehensive approach metabolomics and handling data analysis by the multivariate analysis and correlation network analysis among different factors in biological systems. This method which can reduce time labor and money consuming can be applied to improve many model studies of natural compounds to narrow the gap between natural products and drug development.

- Publications:

+ 02 articles in qualified International Scientific Journals;

+ 02 articles in National Scientific journals;

+ 02 papers in National Conference(s).

- Training: 02 Masters

3 years

(2017 - 2020)

6

Designing and screening nature derived compounds from Vietnamese plants oriented anti-hepatocellular carcinoma activity.

Dr. Pham Minh Quan

 - Virtual screening in combine with design optimal structure of potential compounds to enhance their potency when tested actual activity on liver cancer cell lines;
 

- Isolation, semi-synthesis derivatives of the potential compounds identified through virtual screening and the ent-kaurane diterpenoid compounds;
 

- Test biological activity of these compounds on liver cancer cell lines, study their mechanisms that activate apoptosis process of the cells.

- Technical Products:

+ The expected results of this project is via virtual screening method, we can identify several potential compounds that could inhibit the growth of liver cancer cells by abrogate the interaction between two protein p53 and Mortalin. In the next step, isolate and semi-synthesis derivatives and successfully test their activity on two liver cancer cell lines HepG2 and Hep3b;

+ Establish and demonstrate the reliability of a new research method for hepatocellular carcinoma, allowing to shorten the time and cost saving process in future study;

+ Study and demonstrate through experimental tests that the mechanisms of action of bioactive compounds on liver cancer cell lines are through the activation of apoptosis process.

- Publications:

+ 02 international scientific journal (ISI);

+ 01 national scientific journal;

+ 01 report at international/national conference.

- Training: 01 Master.

2 years

(2017 - 2019)

 

 

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