In this project, the design of organic materials (conducting, semi-conducting) and metallic nanoparticles will be emphasized with development in environmental and biomedical applications. The first applications to be developed concern environmental and biomedical sensors.
Despite some recent advances, the detection of traces of (bio-)chemical contaminants in food or environment (water, soils …) as well as biomarkers specific of some diseases in medical diagnosis remains a challenge, in France or in Vietnam. For example, one of the most rapidly advancing fields in medical diagnosis is point of care (POC) testing. The aim is the development of potentially portable set-up that allows a whole diagnostic panel directly on-site (in the doctor's office or the emergency ward, for example) where regular assays cannot be performed since they are time-consuming. For other applications, the rapid detection of contaminants is important to estimate any damage on the environment, or for food quality control. Analysis are currently achieved through very classical tools such as chromatographic techniques coupled to mass spectrometry.
Due to their complexity, the design of highly sensitive and specific sensing devices requires an interdisciplinary collaboration (chemistry, physics, and biology) and complementary expertise between research groups that cannot be found at a single laboratory level. Via an international research project, one can take profit of the most recent advances in nanomaterials, micro- and bio-technologies to develop innovative biosensors devoted to the detection of contaminants and biomarkers, able to detect traces with high sensitivity expected around the sub-femtomolar (10-15M) range.
With the view of potential applications in environment, biology and medicine, the development of such sensors at the nanoscale must gain much attention in this program. Due to confinement and plasmon effect interesting novel properties can be anticipated at the nano-structuration scale. Elaborated coordination complexes are versatile; one, two or three different ligands can be organized around the metal in order to insure (i) a robust interaction with a surface (they can be covalently bonded to a silica, or metallic surface), (ii) physical property, and (iii) free position for potential reactivity with a gaz.
PI : PHAM Minh Chau, Paris Diderot
Co-PI : TRAN Dai Lam, IMS-VAST
NGUYEN Tuan Dung, ITT-VAST
UNG Thi Dieu Thuy, IMS-VAST
VU Hoang Chung, IMS-VAST
NGUYEN Quang Liem, IMS-VAST
VU Thi Thu, USTH
Benoit PIRO, Paris Diderot
Jean-Christophe LACROIX, Paris Diderot
Marion WOYTASIK, Paris Sud
Philippe LECOEUR, Paris Sud
Fayna MAMMERI, Paris Diderot
Steeve REISBERG, Paris Diderot
Nordin FELIDJ, Paris Diderot
Delphine SCHAMING, Paris Diderot
Pascal MARTIN (Paris Diderot)
Jalal GHILANE, Paris Diderot
Catherine AMIENS, Université Paul sabatier
Diana CIUCULESCU, Université Paul Sabatier
Karine PHILIPPOT, Laboratoire de Chimie de coordination CNRS
Pierre LECANTE, Centre d'Elaboration et d'Etudes Structurales CNRS
Gilles LEMERCIER, Université de Reims
Philippe DANIEL, Université du Maine
TRAN Ving Hoang, USTH Phd Student